Early Stage Researcher, Molecular Biology

The University of Eastern Finland is inviting applications for an Early Stage Researcher in Molecular Biology - position in Joensuu campus. The position will be filled for a period of four year starting from September 1, 2021. Please find more information below and submit your application no later than 3 August 2021. 

Role and salary

The research project, funded by the Academy of Finland, aims to understand the processing of stalled mitochondrial DNA (mtDNA) replication forks, their relation to mtDNA integrity and cellular signalling responses. The PhD student will investigate the role of two proteins in the cleavage of stalled mitochondrial replication forks, the fate of broken mtDNA in cells and the signalling pathways that react to mtDNA damage or interact with extramitochondrial mtDNA.

Positions of Early Stage Researchers shall always be filled for a fixed term (UEF University Regulations, Section 31). The position will be filled for a period of four year starting from September 1, 2021. A probationary period is applied to all new members of the staff.

The salary of the position is based on the salary system for the teaching and research staff at universities. The salary consists of the job-related salary element and the personal performance salary element. For this position, the job requirement level used to determine the job-related salary element is 2–4, and the personal performance salary element is 6–50% of the job-related salary element. The estimated monthly salary in the beginning of the employment will be 2,288.17- 3,163.95 €/per month. The salary of an early stage researcher depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

As Early Stage researcher your main responsibilities will include:

  • Manipulation of enzymes involved in mtDNA maintenance using siRNA knockdown, CRISPR/Cas9-knockout and induced overexpression in cultured cells
  • Analysis of mtDNA replication intermediates and stalled replication forks using agarose electrophoresis and transmission electron microscopy
  • Investigation of the signalling pathways affected by mtDNA damage or mtDNA escape from mitochondria by Western blots, inhibitors and knockdown of key components
  • Research visits to collaboration laboratories
  • Presenting of research results in international conferences and publishing results
  • Writing of a Ph.D. thesis

Our requirements and expectations

A person to be appointed as an Early Stage Researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree or an equivalent education abroad, which in the country in question would qualify the person for similar academic studies. A master’s degree or equivalent in molecular biology, cell biology, biochemistry or a related field is required for the position. Persons graduating in the near future are also encouraged to apply. However, they are expected to hold a relevant M.Sc. degree (or equivalent) by the starting date of the Early Stage Researcher position.

Potential candidate should have good command of the English language. We expect the student to have good prior knowledge of molecular biology methods and cell culture. Previous experience with mitochondria or mitochondrial DNA metabolism is a plus.

Your benefits

You will have access to the university’s staff benefits, including

  • extensive occupational health care
  • staff discount on lunch in our campus restaurants, as well as on a range of other services
  • affordable sports services. 

Please read more in the Work at UEF section on our website.

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community.

How to apply?

Submit your application by using our electronic application form no later than 3 August 2021 (by 24.00 hours Finnish time)

Please note that you must include the following appendices in your application:

  • CV (max 2 pages http://www.tenk.fi/en/template-researchers-curriculum-vitae including possible publications)
  • a motivational letter and the contact details for one or two references
  • copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas 

Questions?

For further information on the position, please contact Senior Researcher Jaakko Pohjoismäki, Ph.D., tel. +358 29 445 3052, jaakko.pohjoismaki@uef.fi.

For further information on the application procedure, please contact Executive Assistant Satu Turunen, tel. +358 29 445 3031, satu.turunen@uef.fi (on vacation July 3- July 30). 

University of Eastern Finland and the Faculty of Science and Forestry in brief

The University of Eastern Finland is the most multidisciplinary university in Finland. We are home to 15,500 students and 2,700 staff members. Our research is ranked among the best in the world in several fields (inc. forest sciences). We generate research-based knowledge and make it openly accessible for the benefit of all. UEF stands for action with impact that is relevant today and tomorrow. To learn more about our university please visit our website at www.uef.fi/en

The Faculty of Science and Forestry operates on the Kuopio and Joensuu campuses of the University of Eastern Finland. The mission of the faculty is to carry out internationally recognised scientific research and to offer research-education in the fields of natural sciences and forest sciences. The faculty invests in all of the strategic research areas of the university. The faculty’s environments for research and learning are international, modern and multidisciplinary.  The faculty has approximately 3,500 Bachelor’s and Master’s degree students and some 470 postgraduate students. The number of staff amounts to 530. To learn more about the Faculty of Science and Forestry please visit our website at www.uef.fi/en/faculty-of-science-and-forestry